The ethics of stem cells: now and forever, cells without end

The promise and potential of human embryonic stem cell research evoke profound clinical enthusiasm1-3; the embryonic human origins of such cells warrants an equally profound ethical concern. The ethical issues are not primarily matters of scientific fact nor of political belief.

Human aging and progeria.

The notion that all aging is ultimately cell aging is a novel hypothesis and one with growing support. Recent studies in genetics and cell biology are consistent with this view. Criticism of the model is largely reflective of inadequate understanding of both the model itself and human pathology...

Cell senescence in human aging: a review of the theory.

Cell senescence limits cell divisions in normal somatic cells and may play a central role in age-related diseases. In this review, we examine the theory that cell senescence underlies and is a pivotal event in human aging and age-related diseases...